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Preferred therapy: Insulin remains the gold standard

If you're eating 2200 calories daily and your maintenance is 2000, no amount of methionine, choline, or B12 will produce fat loss

I dont think so

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In animals, specifically DR in its various forms (CR/IF/STS, KD, protein restriction) has shown a potential for simultaneously targeting many of the pathways associated with insulin and IGF signaling, usually with no serious, or with even beneficial side effects such as a differential stress response between normal and tumor tissue

The results are strong, the science is solid, and decades of data back it